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What will the journey look like for me or my loved one?
TECELRA is a personalized, one-time therapy that is different from other synovial sarcoma treatments
Dosing for TECELRA is unique—after pre-treatment, it takes a single infusion of your own engineered T cells to target and destroy synovial sarcoma cells in your body. Learn more about each step of the treatment journey below.
1
Biomarker testing for eligibility
This is how your medical team will determine if you are able to receive TECELRA. You will need:
- A blood test to determine if you express a specific genetic marker—an HLA protein on your cells†
- A tumor tissue test to check for the biomarker called MAGE-A4, which is the protein TECELRA is designed to target on tumor cells
2
T-cell collection
Your T cells are collected from your blood through a process called leukapheresis. They are then frozen and shipped to the manufacturing facility to create your personalized treatment.
TIME: Up to 8 hours
LOCATION: TECELRA Authorized Treatment Center (ATC)
3
Cell manufacturing
Next, your T cells are thawed and engineered to create TECELRA. This is done through a genetic process that changes your T cells so they target tumor cells in your body.
Your modified T cells are checked for quality and then frozen.
TIME: About 6 weeks (time may vary)
LOCATION: US WorldMeds’ specialized manufacturing facility
After passing a quality check, your frozen engineered T cells are transported back to the ATC where you will receive treatment.
Your ATC stores these frozen engineered T cells that make up TECELRA until it is time for your TECELRA infusion.
4
Pre-treatment lymphodepleting chemotherapy
Before receiving TECELRA, you will undergo lymphodepletion, which is a short-course pre-treatment chemotherapy regimen that lasts 4 days. This is different than a normal course of chemotherapy used to treat cancer, as lymphodepletion is intended only to prepare your body to receive your engineered T cells. This 4-day regimen will start 7 days before your TECELRA infusion.
TIME: 4 days
5
Administration of TECELRA
When it's time to receive your uniquely engineered TECELRA, your treatment team will thaw your stored T cells and administer premedication. This will consist of an antihistamine and acetaminophen 30 minutes to 1 hour before your infusion to help prevent reactions. Then you will receive your TECELRA infusion, which can come in 1 or more infusion bags and may take up to 1 hour per bag.‡
TIME: Up to 1 hour for 1 infusion bag‡ + premedication time
TECELRA is administered by a dedicated treatment team. Talk to your doctor to learn how you can get access to TECELRA.
Find a Treatment Center
6
Monitoring after infusion
After your TECELRA infusion, your care team will check to see that your treatment is working and help you with any side effects that may occur. TECELRA may cause side effects that can be severe or life-threatening. To learn more about these side effects, explore Possible Serious Side Effects.
After infusion, you will be monitored daily for at least 7 days at the healthcare facility where you received your treatment. You should remain close to a healthcare facility for at least 2 weeks following your infusion.
See Important Safety Information, including Important Warning, below.
TIME: At least 2 weeks
Although your journey with TECELRA will take time, you're not alone. Explore the Treatment Support Program to see how you can get help every step of the way.
HLA=human leukocyte antigen; MAGE=melanoma-associated antigen.
†
Positive for HLA-A*02:01P, -A*02:02P, -A*02:03P, -A*02:06P, and negative for HLA-A*02:05P.
‡
A dose of TECELRA may be contained in 1 or more infusion bag(s). A healthcare provider will determine the number of bags needed for your dose of TECELRA before preparing your infusion.