TECELRA is a TCR T-cell therapy, which is a different type of treatment approach that is personalized to you. TECELRA is made from T cells from your body that are engineered and placed back into your body. These engineered T cells work with your immune system to destroy the cancer cells.
WITH TECELRA
T cells play a big role in your body's immune response. They have special proteins on their surface, known as T-cell receptors (TCRs), that can recognize things that may harm the body, like tumor cells. This allows them to target and destroy the dangerous cells.
T cells play a big role in your body's immune response. They have special proteins on their surface, known as T-cell receptors (TCRs), that can recognize things that may harm the body, like tumor cells. This allows them to target and destroy the dangerous cells.
SYNOVIAL SARCOMA TUMOR
SYNOVIAL SARCOMA CELL
Synovial sarcoma cells, like other cancer cells, try to hide from your T cells by stopping or limiting the display of certain proteins on their surface. These proteins are how T cells identify cancer cells, so this makes it harder for T cells to find and attack the cells.
ENGINEERED T CELL
ENGINEERED TCR
TECELRA is made by collecting your own T cells and engineering them to have modified TCRs. These TCRs have an enhanced ability to recognize a type of protein called MAGE-A4 that can be displayed by synovial sarcoma cells.
Synovial sarcoma cells, like other cancer cells, try to hide from your T cells by stopping or limiting the display of certain proteins on their surface. These proteins are how T cells identify cancer cells, so this makes it harder for T cells to find and attack the cells.
ENGINEERED T CELL
ENGINEERED TCR
SYNOVIAL SARCOMA CELL
Once engineered, the T cells with enhanced TCRs are put back into your body in a single infusion, where they target and destroy synovial sarcoma cells.
MAGE=melanoma-associated antigen; TCR=T-cell receptor.
MAGE=melanoma-associated antigen; TCR=T-cell receptor.
T cells play a big role in your body's immune response. They have special proteins on their surface, known as T-cell receptors (TCRs), that can recognize things that may harm the body, like tumor cells. This allows them to target and destroy the dangerous cells.
Synovial sarcoma cells, like other cancer cells, try to hide from your T cells by stopping or limiting the display of certain proteins on their surface. These proteins are how T cells identify cancer cells, so this makes it harder for T cells to find and attack the cells.
WITH TECELRA
TECELRA is made by collecting your own T cells and engineering them to have modified TCRs. These TCRs have an enhanced ability to recognize a type of protein called MAGE-A4 that can be displayed by synovial sarcoma cells.
WITH TECELRA
Once engineered, the T cells with enhanced TCRs are put back into your body in a single infusion, where they target and destroy synovial sarcoma cells.
MAGE=melanoma-associated antigen; TCR=T-cell receptor.
TECELRA® is a medicine, called a genetically modified autologous T cell immunotherapy, that is used to treat synovial sarcoma. It is used when other kinds of treatment do not work. TECELRA is different from other cancer medicines because it is made from your own white blood cells that are made to recognize and attack your cancer cells. Your healthcare provider will perform tests to see if TECELRA is right for you.
Important Warning: You will likely be in a hospital before and after getting TECELRA. TECELRA may cause side effects that can be severe or life-threatening. Call your healthcare provider or get emergency help right away if you get any of the following: fever (100.4°F/38°C or higher); chills/shivering; difficulty breathing; fast or irregular heartbeat; low blood pressure; fatigue; severe nausea, vomiting, or diarrhea; severe headache; or new skin rash. Tell all your healthcare providers that you were treated with TECELRA.
TECELRA® is a medicine, called a genetically modified autologous T cell immunotherapy, that is used to treat synovial sarcoma. It is used when other kinds of treatment do not work. TECELRA is different from other cancer medicines because it is made from your own white blood cells that are made to recognize and attack your cancer cells. Your healthcare provider will perform tests to see if TECELRA is right for you.
Important Warning: You will likely be in a hospital before and after getting TECELRA. TECELRA may cause side effects that can be severe or life-threatening. Call your healthcare provider or get emergency help right away if you get any of the following: fever (100.4°F/38°C or higher); chills/shivering; difficulty breathing; fast or irregular heartbeat; low blood pressure; fatigue; severe nausea, vomiting, or diarrhea; severe headache; or new skin rash. Tell all your healthcare providers that you were treated with TECELRA.
After getting TECELRA, you will be monitored daily at the healthcare facility for at least 7 days after the infusion. You should plan to stay close to a healthcare facility for at least 2 weeks. Do not drive, operate heavy machinery, or do other activities that could be dangerous for at least 2 weeks after you get TECELRA. Your healthcare provider will do blood tests to follow your progress. It is important that you have your blood tested. If you miss a scheduled appointment for your collection of blood, call your healthcare provider as soon as possible to reschedule.
Before you receive TECELRA, tell your healthcare provider about all the medicines and supplements you take and your medical conditions, including: seizure, stroke, confusion, or memory loss; heart, liver, or kidney problems; low blood pressure; lung or breathing problems; recent or active infection; past infections that can be reactivated following treatment with TECELRA; low blood counts; pregnancy, you think you may be pregnant, or plan to become pregnant; breastfeeding; or taking a blood thinner.
The most common side effects of TECELRA include nausea, fatigue, musculoskeletal pain, infection, fever (100.4°F/38°C or higher), constipation, vomiting, headache, diarrhea, cough, fast heart rate, swelling, shortness of breath, rash, increased aspartate aminotransferase, increased alanine aminotransferase, decreased lymphocyte count, decreased white blood cell count, decreased neutrophil count, decreased red blood cell count, and decreased platelet count.
You are encouraged to report side effects to the FDA at (800) FDA‑1088 or www.fda.gov/medwatch or to US WorldMeds at 1-855-246-9232.
TECELRA® is a medicine, called a genetically modified autologous T cell immunotherapy, that is used to treat synovial sarcoma. It is used when other kinds of treatment do not work. TECELRA is different from other cancer medicines because it is made from your own white blood cells that are made to recognize and attack your cancer cells. Your healthcare provider will perform tests to see if TECELRA is right for you.
Please see Medication Guide, including Important Warning.
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